Not out of the box. However a couple tactics could be used to force VMs to reside only on a subset of hosts.
1. (not tested but in theory should work):
Use storage policy, so that the VM will be placed on storage only available to a subset of hosts.
2. (better way I think)
Use the VCD AMQP task handling to integrate a solution like VCO, from VCO you could detect the vApp creation and place the VM in the group. Also on vApp delete you could remove the DRS rule.
Hope that gets you going in the right direction.